Powder specific!
Fairly new to loading. I'm making a batch of .357 with 15g Alliant 2400, CCI 500 Primers and 125gr jacketed. Load manuals call for small pistol primers.
I'm almost out of the CCI 500 but have 1000 1.5 Remington's small pistol and 1000 CCI 550 magnums. The Remington's say not to use on magnum loads on the box. If I use the CCI 550s do I need to adjust my load and by how much or should I just not bother with the 550s and just go buy more 500s. What is the effect of the 550 vs 500
mboy,
What primer you use is usually more powder specific than load specific. HS-6, no matter what kind of load you are doing requires a magnum primer. Even folks that like that powder, I happen to be one of them, will tell you that it just settles down when use magnum primers.
On the other hand, 2400 is touted as not needing them to perform well. Now, your question is a good one: "If I switch primers, do I need to change my load?" That, dear friend, is a perfect question.
The answer is pretty simple too. DEPENDS!

What I mean is this, if you worked your current load up using a standard primer and are at the top of the loading data then the answer is yes, reduce your load and to be safe, start back at the low end.
Now, here is where I will differ with most folks: "If you are in the middle to lower end already, AND HAVE A CHRONOGRAPH, you can take off from where you are, again, this is just my opinion.
Load 6 or so, again, if you are already at the lower end of the data, change the primer and see what you end up with across the chronograph. If it is in the middle to upper end of the velocity data, stop. You are at maximum for the components you are using.
Because I generally load to the middle of all the data I use, this is what I do. That being said, I have only ever seen about 100fps from the same firearms with the same loads after going to magnum primers.
You do what you feel is best for you. The proper instruction is to start completely over with the change of any one component. To be safe, that is what you should do. I told you what I do.
Being full grown means you get to make your own decisions. You also get to live by the results of those decisions.
Have fun, be safe.