My Ruger #3 had a 1-16 twist. A carry over twist rate, from old .22 LR barrels, that were often used for the Hornet way back when. Usually 45 gr bullets or less are tops for best accuracy. It's not the weight, but the bullet length that matters in determining the proper twist rate for bullet stability. Notice that dedicated Hornet bullets are more blunt than regular spitzers of similar weight, which shortens the length for the slower Hornet twist. I had best results with Lil Gun powder. It is recommended to try pistol primers in the Hornet with your load development, as it is theorized that a standard rifle primer will drive the bullet out of the case before the powder can be sufficiently ignited. This can cause erratic grouping. Try and see if it makes a difference.
I ultimately tired of the Hornet, and rebarreled it myself, to .357 magnum, which I thought was a more useful cartridge for my purposes.