Newer .45ACP revolvers, which I believe includes all Model 625 revolvers, have some sort of a ledge inside the chamber, but I am quite sure that they are NOT designed to properly headspace the case. I have a cut-down 25-2, a 22-4 and a 325PD. Loading the 25-2 sounds and feels like six clicks; loading the others is a more or less muffled squish into place. For years the newer guns seemed to work OK, although I never really trusted them without clips. Finally, within the last year or so, I got some failures to fire with the 325.
The new guns are obviously designed solely for clips. If they actually work without them, fine, but don't count on it. S&W didn't.