The origianl poster is probably referring to the fitting of a .45 Colt N frame barrel with a shorter shank than that of the .45 ACP barrel on an M25-2. The .45 ACP cylinders are shorter than the .45 Colt cylinders, and the barrel shanks are different lengths.
Yes, it is "do-able". The twist rates should be identical. The loss of a couple three threads on the barrel shank poses no problems.