I had my 625 rechambered to 460 Rowland a long time ago. So it shoots 45acp, 45acp+P, 45 Super as well as 460 Rolland. Clark would not rechamber the 625 to 460 Rolland if it was not safe to do.
Something not to do is load Super loads in standard brass.
In Starline Brand the light stuff is 45acp, +P brass is a little heavier made, and the Super and 460 Rowland are the same brass case as 45 Win Mag only shorter.
I have never fired a great deal of 460 Rowland or 45 Super ammunition through my 625, but I see no reason not to. AS was siad above it is still not all that hot as compaired to a 44 Magnum. I believe Super is loaded from 22,000 to 28,000. The newer Buffalo Bore is on the lower pressure end.
CAUTION: The safety issue with 45 Super ammunition has never been with modern revolvers. It is with getting the hot 45 Super ammunition into a 1911 not set up to handle the higher pressure loads. I am not sure of all the work done to a 1911 to shoot 45 Super without damaging it by Ace, but heavier recoil springs ( 20 - 32 Pound) and a shock buff, special recoil guide, different firing pin retainer, heavier firing pin spring, some times heavier magazine springs, and ramped barrels are listed as modifications to handle the 45 Super. Be sure to keep your Super ammunition away from a non-modified 1911. This is the reason for the 460 Rowland case being slightly longer than a 45 acp/Super, it will not chamber in a 1911 not set up to shoot it. A safer way to go if you also own a 1911 the ammunition could get in. This is why my cylinder has been rechambered for 460 Rowland, I also own a custom 1911 Colt I do not plan to damage.
Bob