I have versions of both. When I qualify for my carry permit, I always use the .45. I have always found the recoil on it notably less intense than the .357. First, the ft-pounds for .45 range from about 350 to 500 while .357 range from about 500 to 800. And as the .45 revolver is usually heavier than the .357, the felt recoil is less. Generally, the grips are wider on the .45 and that also spreads the recoil over a larger area, further decreasing the recoil impact. I always shoot better with my .45 revolver than with my 45 autos. My testers for my carry permit are always surprised by that, but the gun runs so smoothly it isn't surprising to me. The moon clip thing seems like a problem at first, but it is so quick to load and unload you will learn to love it. No more bulky than speed loaders, but much faster. Putting the round into the clips and removing the empties are sort of like a little Zen exercise for me. I find it very relaxing and calming (really!!). AS other have said, cost is not really a big difference. You can usually find on line sales which will bring the prices close together. If you have to buy only one, get the .45.