I don't keep anything in my sock drawer, except socks.
BUT, I think if one has more than one handgun, it makes sense to keep them available at strategic places within the home (assuming one doesn't have inquisitive little kids roaming around).
I started with Sigmas since, and please forgive me Sigma owners, no one really wanted them and they were dirt cheap on the used market.
Then I changed to revolvers since I didn't want my wife to have to worry about the manual of arms for an auto, when she could just point and click, so to speak, with a revolver.
So, I have stashed a number of J-frames, a Cobra and, for me, a Glock 21 in a special place.
Works for me and must be effective as I have never had to use a single one of them to protect our home.
Bob