Best for what?
For sheer excellence of execution, my 4" Model 29-2, proudly crowned with the best grips ever made for it, Pachmayr SN-S Presentations.
For best defensive weapon, probably my roundbutted 25-2 with 4.25" cutoff barrel with serrated red-insert sight and narrow rounded and polished trigger and chamfered chambers, and Pachmayr (sound familiar?) Compac grips.
For slightly more comfortable carry for defensive purposes, either of my Improved Model 56 revolvers, AKA 2" Model 15, with bobbed hammer and Rogers/Safariland grips.
That's revolvers. Best trigger and probably accuracy on any of my handguns probably comes from my H&R USRA Model 195 with adjustable sight radius and Roper grips. [The Roper grips are probably also a repeat, since it seems pretty obvious that the Pachmayr Presentations are a copy of the Roper design.]