Personally I can't really understand WHY you would want to carry a huge and heavy Revolver in Florida. Even though you say you are able to conceal it, it has to be cumbersome and annoying in Florida's hot & humid season. If there are no other options of defensive handguns for you - then I understand but personally I'd opt for a smaller and lighter defensive firearm. The M625 is a great Revolver in a great caliber, however I never thought of it as a CCW Revolver.
As far as the lock up points are concerned, the two there are more than adequate and you will not have any issues with defensive ammunition. This basic design has been around for a century and it seems to work just fine.