I have several .45 Colts, and plan to add more to the menagerie. At present I have a 25-5, a 625-6 Mountain Gun, a early Vaquero and a Marlin 1894. I used to have a Ruger Alaskan .454 that I only shot with .45 Colt, and a Taurus 450. Just the other day I was looking at a Redhawk .45Colt/.45ACP, and will probably get myself one as a birthday present in March. I would also like to get a 25-7 or 25-9 at some point as well.
The .45 Colt is a great cartridge to shoot, and very versatile. I primarily punch holes in paper with mine, although I do shoot metallic silhouette with the rifle. The versatility really comes out if you reload. I would pick a Ruger if you plan to use very heavy loads, since the Rugers are built to take abuse. Besides, why beat up a nice S&W.