I voted in the poll based purely on the thread title, before having read the other conditions in your first post.
That having been the case, I voted for the CZ, specifically the CZ75/85, as I own and have extensively fired a pair of each of these (2 of each, 4 total.) In my 21+ years of having owned and fired these pistols, I can't recall one single incident of any of them ever malfunctioning in any way.
Additionally, in terms of my recommending them to an unknown user, without any knowledge of that users physical characteristics (again, before reading your first, or subsequent, posts which clarified this) the CZs came easily to my mind as they offer, IMO, the best shaped grip, which is most likely to be easily held by a wide variety of shooters, while still holding a relatively large capacity magazine within that grip frame.
Another nice feature of the CZ (at least the 75/85 series) is their ability to be carried cocked and locked. Should the owner decide that DA/SA isn't all it's cracked up to be, he can utilize this condition one cocked and locked mode. It's kinda like 2 pistols in one.
A previous posters point about the myriad ways that a DA/SA pistol may be manipulated is somewhat valid. Some would opine that options are a good thing, keeping in mind that the end user should familiarize himself with all of these options, and then select the one that he finds best for him, and thereafter only use that method...which eliminates the potential confusion the poster hinted at.
Lastly, the CZs have always been very affordable. I haven't priced them recently, but the last I looked they were very competitive, and accessories always seemed fairly abundant, and affordable as well.
Now that I have read more about your (or rather, your friend's) needs, I can certainly understand that the Beretta would seem a very good choice, seeing as how you say he has large hands (the Beretta being a large pistol, this is the reason I didn't initially recommend it, without knowing the specific details), and he has some experience with the Beretta.
Tim