A1racer, glad you had success, don’t be surprised if you find both loads to be very good. In the end there are a lot of ways to get this particular job done.
Accurate # 2 & # 5 meters really well, when you use a powder measure metering is important, no make that, very important. #2 is considered “fast” powder, while HS 6, AA #5, and Power Pistol are “medium”.
For medium velocity w/mid-wt bullet loads in the .40 S&W #2 is fine. Many target loads are made up with fast powders, but it’s not usually considered the way to approach high velocity & heavy bullets