I'm not as much of a 1911 aficionado as many here, but I would agree that it would be hard to make a "wrong" choice.
Of your choices, I would narrow it down to Wilson vs. Brown.
Les Baer's always seemed to border on "too tight" for me (but they may be just fine for everybody else). Plus, if I'm not mistaken, they're set up in such a way that you can't slingshot their slides (I'd like to have that option); I hope someone corrects me if I'm wrong.
I don't actually know much about the Nighthawks, but from what I've seen they don't seem to offer anything that really appeals to me, usually too much of something or not enough of something else...I can't remember, exactly...it's been a while since I've looked at their offerings. [Sidenote: I am intrigued by their Hi-Power, though.]
I like the fact that both Wilson and Brown give customers a variety of options. Personally, I went with Ed Brown for the vote. I've even played with the customization page on his website. I particularly like that I could select a 4.5-5lb trigger option as I prefer a heavier trigger on 1911s. I'm rather fond of the two-tone Special Forces Carry Bobtail model, with some VZ Tactical Carry grips (it's not like I've given it much thought, or anything...

).
However, if I were going to spend that much money on a 1911, I would most likely have one custom built by JD Harrison as I'm rather fond of his retro options.