Being disabled, I don't have the luxury or ability to run from danger like I was once able, so finding cover and making a stand is now the priority.
At some point in our lives, we all will lose much of our physical ability to react quickly and effectively. Age will eventually rob us of our strength, speed and mobility. Injury or illness may take it sooner for some.
I currently actually have more semi-automatics, but envision a day when I own nothing but revolvers. They are simpler for aged minds and more reliable in elderly hands.
For those with limited mobility(whether just difficulty walking and general getting around or even those confined to a wheelchair) I would assert that the revolver is the most logical choice.
The inability to flee also means less ability to instantly create space or "get off the X". If you are struggling to simply walk, it will take a large portion of your focus and you are therefore less capable of being tuned in and aware of what's going on in your surroundings due to your overall movement being limited(turning, looking around)as well as being distracted by pain. That means even more compressed time frames that you have to react within.This would be exceedingly true for folks with severe mobilty issues and such issues often don't always occur in isolation as other accompanying ailments affect competence in using a weapon.
Also, those of advanced age or are otherwise ill, generally tend not to have the greatest situational awareness or fastest responses and reflexes. Plus criminals would likely see them as an easy target.
Due to those reasons, the probability of the scenario being close contact is even greater and it is in those types of scenarios that the revolver really shines. Specifically the hammerless snub. That doesn't mean an auto can't effectively be used, I just think a wheelgun makes a lot more sense.
A lot of folks seem to envision armed defense as some kind of shootout situation, but those are extremely rare in the civilian context. If you have to make a stand, it will likely come suddenly and be at contact distances out to a few feet or yards. With age and disability comes greater need as well as legal leeway in being able to use a gun due to disparity of force. A young, strong unarmed man assaulting a disabled or elderly individual could definitely warrant an armed response being justifiable, appropriate and necessary.
For a car gun to respond to car-jacking attempts or driving through an area of social unrest where driving away is not an option, a revolver would again be more suitable IMO for shooting from the likely close, awkward, one handed positions.
Just my take on the subject. YMMV