Years ago, I found that the two piece S&W boxes were great for sorting brass while reloading. 

Is it possible that S&W may have occasionally shipped a gun with grips not numbered to the gun?
I have a K22 with SN K1322X that has grips numbered "10851" but fit perfectly. I purchased this gun from an older gentleman who said he purchased it new on January 20, 1948 from a very small gunshop in upstate NY (Castile). He gave me the original store receipt when I bought the gun. He paid $65.00 for it back in '48. He did not have the box for the gun. Darn!
So did S&W occasionally let guns go with un-matched grips?
Jolly
The first gun I bought was a S&W 48-4. One of the first things I did was to buy target grips to replace the magna grips. I saved the original grips, but a lot of people didn't. I remember going into a local gun store and the owner had a box full of magnas. I wanted to sell the magnas I had and he said "Oh, you want to sell the grips that nobody wants?" So, I kept them.
Years ago, I sold a Colt ACE on consignment. I sold it without the box. 20-30 years ago, I don't think boxes were all that important. Later, I found the box and sold it on Ebay for $165.00. I threw away my first Python box as well as my first Gold Cup box.
Now, I don't throw away anything.