That’s what I used to use, and likewise never really checked the 4.0 grain load very well at 50 since most of my shooting was done at any indoor 25-yard range. We used 3.0 with .38 wadcutters, in both the 52 and revolvers, with good results.
I agree with BE Mike that the best bullets will probably make more difference than any type of powder, but I recall Gil Hebard made a convincing case that the early 52s he tested (I think he had either 5 or 7 of them) were powder sensitive and tended to favor Unique, which surprised me. So I had to try it in my gun, but couldn’t really detect much difference between Unique, 700X, and Bullseye. I think all my testing was done with the Lyman 35863 wadcutter seated flush. Possibly not the best bullet for a .38 wadcutter accuracy test, but it was what I had.