Pythons are fine revolvers, but they tend to have timing issues relatively quickly in their life cycle. Further, I prefer the S&W action over the Colt action by a wide margin. Admittedly subjective, but I'll take the Model 27 (or most other medium to large frame S&W revolvers) over the Colt without a second thought.
When I started as a Police Officer in 1977, my first (personally owned) duty gun was a 4" Model 28-2. It was a tank, and I loved it. After that, it was the typical 19/66 revolvers. Today, I'd have the 28 back, but that's what nostalgia does to you.