A 22RF is not enough to reliably kill a coyote. Can it be done, yes......but not consistently. These are pretty tough animals and you need something to anchor them or else they'll just run off and die, or linger wounded for a while. When we used to hunt them in upper NY state we used 12 guage shotguns, and mostly night hunted (legal there). The shotgun was due to the thick woods in upper NY. In AZ we use any good 22 centerfire or up, with 243 being a good caliber. Much more open, and longer shots here. If you're limited to RF calibers where you hunt then stick with the magnum. If not, I'd suggest a small centerfire rifle round or shotgun, depending on the terrain. Or any good centerfire revolver that you can shoot well.....