I started carrying the so-called "FBI load" about 40 years ago, primarily in a 2.5" Model 19 that was my carry gun working plain clothes law enforcement. Bought the Federal brand .38 Special +P 158 SWC-HP, probably went through 500 rounds or more from late 1970's to early 1990's. Still have a box or two in the ammo locker.
Basic spec was about 900FPS out of a 4" revolver. Remington also had a piece of the same market with a comparable load.
Main thing to understand with these, and most other lead bullet factory ammo, is that the bullets are swaged (cold-formed under pressure in a die to final form), a process that requires nearly pure lead. Bullet lubrication was minimal, an applied slurry of graphite-based emulsion. Pure lead is relatively soft, which allows for upset and expansion on impact, but also allows powder flame temperatures to melt bullet bases and generally smear lead over the cylinder walls, cylinder face, barrel forcing cone, and inside the bore.
Cleaning the revolver can be a real chore after each range session. I always used a new bronze bore brush, used dry to cut through lead wash and deposits prior to solvent and patches to complete the cleaning process. Our department qualification was 50 rounds, done every 6 months, so I just fired up my carry ammo each range day and replaced it with new ammo. My expense reports of the period indicate that I paid $12.70 per box of 50, back in the day, at the regional law enforcement supply company (no federal excise tax on LE sales).
I would not advise shooting more than about 50 rounds before cleaning. The lead transfer was always heavy, and extensive shooting would undoubtedly make cleaning more and more difficult. Wouldn't surprise me to see revolvers start to jam up from lead residue on the cylinder face and barrel forcing cone if a range session went on too long.
Glad to say I never had to use this ammo against a 2-legged target, although I think it would probably perform as well as anything for that purpose. I did have occasion to dispatch a couple of deer that had been struck by automobiles, as well as a 250-lb. sow pig (NEVER RUN OVER A PIG IF YOU CAN AVOID IT!!!). All were clean kills at close range, and no exit wounds were found. I'm sure that the "experts" can provide all sorts of data from ballistic gelatin testing (including multiple layers of denim or leather), but I'm thinking that mammals of 150-250 lbs. weight still wrapped in God's hide and hair, and with functional cardio-pulmonary systems and intact skeletal structures, provided pretty good testing media.
Lots of other choices available now, but the +P 158 SWC-HP is still a very effective choice for defensive use in my opinion.