IMHO the 649-3 without a question.
The shroud (humpback) adds mass to the gun, and keeps the hammer from snagging - but you can still shoot it single action if you like. The -3 and the -5 are both 357 (beefier top strap and barrel) however the -3 has no ILS.
I have a 649-5, and it's my EDC. Before I got this sweet little gun I was only armed some of the time. Now it's all of the time, usually in my pants pocket with a Galco pocket holster, but I also have a Galco V-hawk IWB holster, and I can forget it's there all day long.
It's a beastly j-frame, I can shoot lots of 357s 158gr in it without pain, using that wood grip shown. It's a surprisingly accurate gun - again I think the weight really helps.
I usually carry it in pocket with a Hogue bantam grip, since it's smaller (and I've practiced with that too). If I take it where there's going to be crowds, like a movie theatre, I load it with the 38spl p+. In the V-Hawk I usually put the RW grip on it, as it still carries well and it's controllable with the hottest loads.
It's one of the best gun purchases I ever made. Yeah, I wish I had the -3, but I don't mess with the ILS, and it's never messed with me.