I do most of my defensive shooting practice 7 to 10 yards out. Point shooting, shooting with both eyes open, drawing and firing, moving and shooting, etc. I also stretch it out to 25 yards just for fun sometimes. Outshot my buddy once at 25 yards with my 442, he was shooting a Springfield XD .45 Tactical.
I am always suprised how difficult it is to hit wild game with a handgun? I practice at 15 to 35 yds with all my handguns, they all wear iron sights, the time before last I was bagging off the hood of my old Landcruiser at about 60 yds with an older Beretta 70s in 22lr, changing up to my Springfield Armory Loaded and finishing up with my old 27-2, that now belongs to my little brother, my buddy was surprised, he was shooting his AR with ghost rings and a 10-22, he declined joining my handgun fun, I am 56, he is 61.
He is a much better shooter than I, but he plays the 7yd game, lots of double taps, and shoots even 44 mags and has a very nice follow up even with the 44 mag. I had respectable groups with all the above weapons, but, when you back up to those ranges with a handgun, have realistic expectations, if your eyes water and you stop in the middle of a cylinder or magazine, you more than likely have just changed your POI, regripping, any of the above will change where those bullets go, don't beat yourself up, just keep practicing, and absolutely nothing is more fun than those 100yd shots on cardboard and hearing that bullet "whop" the target, my best group at 100yd was with a Ruger Blackhawk convertible, with the ACP cylinder, 4 shots into 6", not sure where the other two went, this was in field conditions.
The only real point of this is it is fun, but up close, it is so much easier, pick up that front sight, put it on the target and follow through, keeping it there, you will hit, its just that simple. The more important element is form, I shoot Chapman modified Weaver, when I pick up a 2 inch snub or a 7.5 inch colt, I have the same accuracy expectations with both, and yes I understand sight radius, but the rear sight is really your eye, as long as you hold your weapon consistantly with a repeatable form, the rear sights of your weapon will frame the Front sight, pick up and hold that front sight the bullets will follow. Billy