I'd purchase a nice, used, M49 with factory stocks and add a Tyler T-Grip along with several boxes of 158gr., LSWCHP +P ammo and a good quality holster, (IWB, pocket, ankle, etc). Once I had those items it would be off to the range to get familiar with everything after which my M49 and I would become pretty much inseparable. That's the "What" part of my answer.
As far as the "Why", well that's easy. I feel that five rounds of .38 Special is sufficient for most self defense scenarios I envision based on my lifestyle, location, etc. The 158gr, +P LSWCHP load was chosen based on reported performance in real world use as well as my personal preference. The M49 was chosen because I like the way the hammer is covered, (no snags when drawing from a pocket or under a covering garment) and it still allows for SA operation if desired. The only thing I might change would be to go with a 3" M49 if I could find one.