Obviously, there can be no single answer to the OP's question. It will be as varied as each individual's situation. The perfect solution for a single man living in an apartment in Chicago is likely very different than for the family living on a 300 acre ranch in Montana. Logistics, local/state laws, population density, LEO response time, potential collateral damage, your friends and associates: the list could fill volumes, and each circumstance may require at least a slightly different approach.
I don't think it's necessary to turn your home into a fortress, just make it more trouble than it's worth. My neighborhood is an odd mix of horse properties, brand-new McMansions, and regular suburban homes. I'm sure not one of my neighbors has the same solutions as I do. Some may not even consider locking their doors during the day, and others have big dogs, big security systems, and big guns out the wazoo (my next-door neighbor is a gunsmith who works out of his home).
For myself, the 642 slips easily into the pocket of my cargo shorts for outdoor summer chores or jacket if I'm raking leaves or shoveling snow. Inside the home, I keep a bright flashlight on the nightstand and a model 64 locked in a quick-access lockbox. I want to be fully awake by the time I have a gun in my hand. I know my home. I know my neighbors. I know my abilities. I don't worry too much about it.
I do have smoke detectors and 4 fire extinguishers in the house and one in the garage (not counting the ones in the cars), however. In dealing with a fire, grabbing a fire extinguisher is the best immediate action. In dealing with intruders, barricading the family in our bedroom and dialing 911 could be the best option. I don't want to deal with getting a possible IV drug-user's blood out of my carpets if I don't have to.