So, my priority is to get the gun back in action quickly if I need to reload, and with as little potential for fumbling the reload as possible. After some experimentation with different combinations (6 rounds, 5 rounds, 4 rounds in different arrangements, etc.), I settled on 4 rounds in the strip. It works for me. I use speedloaders now, but I still practice occasionally with strips in case I need reloads with a lower profile...
Now that I read your post and go over what deBettencourt et all have said, 2x2 probably makes more sense than a full six because most people switch hands when unloading and loading and by the third step when you're ready to close the cylinder returning the last two rounds to the pouch is wasted motion and another step to Fumble.
Reloading a revolver is harder and more time-consuming and attention focusing then using a speed loader and certainly putting a magazine into a semi auto well that said I guess if I have the time to reload hopefully I have the time to return the last last two to the pouch even if it is a bit more fumble prone than using magazines in a semi-auto. Because it's a revolver I like carrying a p32 as a backup with a ten round magazine.
I also don't really notice a big difference between 4 and 6 on the strip because I just tend to grab the whole thing gross motor and pinch the first two rounds on the gap between my forefinger and thumb and then index into the first two holes. After that I just rotate the cylinder clockwise for the next two strip close ready to go. I like loading 6 because it gives me more to grab onto gross motor. regarding speed strips in vs speedloaders I carry one strip on the Belt in a tuffs velcro pouch. It's much lower profile than anything carrying a speed loader and easier to thread on a belt.
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