I believe the mental process of choosing the right gun for you to use anytime is more important than the gun you eventually end up with. That will vary greatly. But the process should be the same. To me these are life and death decisions.
Most of us civilian concealed carriers operate in fairly low threat environments. Statistics prove encounters are close and only require a minimal number of rounds, and often any caliber will do. So most CCW's base their decisions on these parameters.
I don't, because averages suck. I prepare mentally, with training and with firearms more oriented toward the outlier negative experiences that disappear in averages. In over 25 years of carrying in low threat environments I have never touched my firearm for a defensive purpose. I am in condition yellow, not white, most of the time.
Only twice have I considered pulling my gun. One was an aggressive road rage encounter and the other was a very aggressive pan handler. I was able to descalate both situations without the gun.
Here are my priorities, mostly in order:
1. Reliable and safe when carried loaded.
2. I can shoot it well, fast, under stress, at close and more extended ranges.
3. I can conceal it well.
4. It shoots a cartridge accepted as adequate for difficult situations.
5. It has enough capacity to deal with multiple opponents, including some misses.
6. With this gun I take one or more self defense handgun courses per year and other dry and live fire practice to stay proficient.
With such a process, mindset and training, the actual choice of gun will vary widely given different individual perspectives. The gun is less important than having the awareness and competence to use it.
I too have experienced a progression of carried firearms. As technology has advanced and publication, even videos, of thousands of armed encounters have become available, my gun decisions have changed. Current training has also changed to be more realistic, and it is rarely just oriented toward "average" scenarios. I expect my gun choice progression may continue, especially as I age and my physical abilities change.
Carry whatever, but have a good justification other than ease or comfort as top priorities for doing so.