I truly did not start to fully enjoy shooting my Smith & Wesson M66-2 until I put the Pachmayr Presentation grips on. They fit my hands like gloves, double or single action, and perfectly comfortable, not a single complaint. That's what it's all about, right?
I did find a little extra "space" between the back part of the grips and the backstrap, thought, this doesn't bother me. It's probably an easy fix with a little elbow grease.
I have kinda small hands - Hogue finger grove grips space my fingers out weird, painfully so. I liked them very much until I actually started concentrating on proper handgun grip. Smith & Wesson wood target Presentation grips, look cool, Dirty Harry nonsense, chew your hands up when shooting magnums out of a K-frame and get very slippery if your hands are prone to sweating (let's be honest about it...) I find myself adjusting every shot if I'm unloading hot Magnum loads out of a K-frame with smooth wood grips.
None of those issues, for me, with a Pachmayr Presentation grips, which absorb some nasty recoil out of such a (relatively) small Magnum revolver, and allow for a natural finger spacing on the grip itself, which is important for us small-handed fellows.