I have a XVR 460 mag. I just scoped. zero is about 2" high at 100 yds. S&W claims a zero hold at 200 yds. which they claim is a kill shot from 0 to 200 yds. with the Cor Bon 200gr. XPB. That sounds a little shaky to me BUT. Any way I'm zeroed in with Hornady 200gr.FTX ammo, which is 100 fps. slower then the Cor Bon ammo at the muzzle. What should my hold be at say 150 to 200 yds? and what should my hold be at say 50yds. ? I looked all over on line for a trajectory scale for this round with no luck. Can any one help me out?

Typically (but I'd verify it out of my own gun) the faster a given load is, the lower it will print, until apogee is reached. Not knowing what the trajectories are of the load means everything mentioned is just guess work. How much lower can only be estimated? Divide the difference in velocity of the slower load, into the overall velocity of the faster of the two loads. So, if it shoots "high" by 2" @ 100 yards with the slower load, and this load is 25% "faster" you could reasonably expect the faster load to print 1/2" lower. This assumes like grain weight and shape bullets. But again, this varies wildly gun to gun.
The answer to your "why is 100 yard POI 2" high" question is likely this. The "cone" of POI between 0 and 200 yards for the load, will allow rounds fired from point blank range out to 200 yards of range using a "dead on" hold, to land somewhere along a 4" high vertical range. Which in most medium/large game is it's "kill zone". Again, all is academic unless THE load, your going to be using in YOUR gun is test fired in actual increasing 50 yard distance increments, three round groups at each distance.
Good Luck!

Using 200 gr FTX Hornady handloads at around 2150 fps, my 460xvr shoots about 1/2" high when zero'd at 50 yds. Between 50 and 100 yds it's essentially flat. I have no data beyond 100yds.