The 10mm is such a versatile round, it can be tapered to fit the needs of the shooter. My Glock 20 shoots them all quite well. I do not really hunt, but there are many full power heavy bullet loads around for that purpose. For defensive loads there are several choices. One would be a heavy JHP (180-200 grains) at full power, which also make good hunting rounds. Another option would be a lighter JHP (135-165 grains) full power load. These seem to optimized for defense, as you have a lighter round traveling at high velocity, similar to the vaunted .357 Magnum. Still another option for defense is the heavy JHP at lower power - often called the 10mm lite or FBI load. Many factory loads are loaded at this power, and are closer in performance to the .40 S&W, and a great example of this is the Federal Hydra-Shok. This is 180 grain moving at around 1050 fps. I like this load in my Glock 20 for home defense, and would work great in a 1911 as well. While it is less powerful, it is an easy shooting load that still offers good stopping power, sort of how sometimes a .38 Special +P works better in some situations in a revolver than the full house Magnums. Also, many target loads seem to be loaded to this lower power as well.
Either way, the 10mm is such a great round, you really cannot go wrong either way!