Dip the case into the powder, hammer a bullet on top. 296 runs best at max...lol!
But seriously, I ran into the same thing you are worried about a few years ago and worked up loads. Two guns loved 21.5 grains, another started to get sticky extraction at 20.5.
I have a Winchester publication from 1982 in which they list the recipes to duplicate Winchester factory loads. For a 125 grain jacketed bullet, they list 18.5 grains of 296, with Winchester primers, which they say has pressure of 32,500 CUP. They say do not reduce that load. Again, this is a factory duplication load, not a stated maximum.
To the question...when there's any question, I defer to the powder manufacturer's data. Hodgdon doesn't manufacture anything, but they own and distribute Winchester powders. From the get-go, Winchester always cautioned strongly against reduced charges of 296...