Most autopistol rounds are designed to headspace on the case mouth. Because of this, those rounds should only be shot in the firearm that is marked for that caliber of ammunition, otherwise a malfunction at best or a catastrophic failure may occur at worst.
However, the above being said, most semi-auto pistols will headspace on the extractor. Not to say it is safe or recommended at all- but it can work.
If he had a modern .45 ACP revolver, he certainly can shoot the .45 GAP's in it with moonclips safely.
Also, .45 GAP is usually more expensive than .45 ACP.