If you want a Python because you think they're neat and just want to have one, then don't let us dissuade you. Go for it. But keep the Smiths. Unless of course you aren't really a shooter but more of a collector.
But, if you want a Python because it's supposed to be the most accurate revolver out there (as some would have you believe), there is a much better approach. Buy a Model 16 with a 6" barrel, have the cylinder rechambered to 38 Special using a tight match chamber, and have the barrel bored and rifled to .356" with a 1 in 14" twist. I did this Bullseye shooting and the results were outstanding. Using WW White Box 38 Special 148 grain Wadcutter, the gun shoots less than an inch at 25 yards and less than 1.5" at 50 yards, and all 6 chambers shoot to group. Hamilton Bowen did the work. Cost of the complete project is just about what a nice Python will set you back, but will provide you the durability and smooth action all of us Smith and Wesson shooter love and cherish so much. To quote from an old Bogey movie, "Pythons? We don't need no stinkin Pythons!"
Looks just like a Model 14 doesn't it?
Keith