I have a very tender spot for beautiful revolvers, especially S&W revolvers, even more especially the Chief's Special and the Model 27. And many posters here have S&W revolvers that cause my soft spot to become vulnerable to sentimental purchases, which is a good thing.
The Chief's Special oughta be on Mount Rushmore as an American icon. But the reality is it's a very poor choice for bipedal self-defense. To reach that conclusion, one has to begin with human biology and human incapacity.
While death is often the outcome of gunfights, it's not the objective. The primary objective has to be survival of good guys. The only known way to survive is to not get into gunfights. If that's not an option, one cannot take a bad guy's rounds. That means a good guy MUST get the heck outta a bad guy's sight picture. Taking precise aim at a bad guy would make a good guy an easy target for a bad guy.
Absent a CNS hit, which is almost always the outcome of luck, human incapacity is a done deal when oxygenated blood no longer flows topside. All death is defined by lack of brain activity. Humans must have topside oxygenated blood flow to remain alive. The problem for good guys is reducing a bad guy's blood pressure to zero takes a lot of precious time, time that accords bad guys ability to kill good guys. And here we haven't considered the probability of a bad guy's use of drugs that skew incapacity. A human being with a heart no longer beating will live another 8 seconds, which is plenty of time to take a good guy with him. Hence, my preference for BIG holes that cause a lot of bleeding.
We've been considering just one bad guy, which would be unlikely in cities of America. Bad guys rarely do bad things alone. The reality is a good guy, upon ID'ing one bad guy, must scan for his buddy, or more assuredly, his buddies. This is where the Chief's Special, all revolvers for that matter, become huge liabilities. The longer it takes to prevent one bad guy from putting rounds on a good guy, the more likely one of his buddies will kill a good guy. If muzzle flash, recoil, or disorienting muzzle blast takes a good guy's gun's muzzle off of a threat, he'll know tactical disadvantage. Hence, my preference for the FBI Load, even in .357 Mag revolvers.
The Chief's Special is a beautiful handgun, in either blued or stainless, but it has severe limitations that can cause a good guy to be autopsied.
As much as I love the Chief's Special, I'd take a Sig P239 in .40 S&W every single time, except where I can conceal a Sig P229 in .40 S&W.