In 1963 I traded into a "Great Western" .38spl Derringer. At 25 yards I was able to keep both shots in the "Kill Area" of a B-27 target.
In 1966 I had a "High Standard" Derringer in .22 magnum. I was still able to put both shots in the "Kill Area" of a B-27 target.
In 1968 I traded into a "Maverick" .357 Derringer-Which I couldn't hit a barn with plus it was "HEAVY" in weight.
In 1991 My shift supervisor had a "High Standard" .22 magnum Derringer that he carried in his right rear pocket as a "BUG". Him and no one else could hit a B-27 target at 7 yards. We never could find where the bullets were going.
My Wife has a small collection of "Little Pistols" which includes Derringers, NAA Revolvers, and .25acp Semi-Autos.
IMHO the rightful place for these "Little Guys" is "Deep Cover" to be used when everything else is out of ammo, been lost, or jammed.
Also has a safety device when hiking in Bear Country with a companion that might run faster than you when being chased by a hungrey/mad Bear.