Ballistics by the inch took a Uberti 1873 Cattleman Single Action Revolver in 357 and set it with no gap, .001 gap and .006 gap and fired a variety of ammo through it first with 18" of barrel, then 16" then 14" and so on all the way down to 2"
BBTI - Ballistics by the Inch :: Cylinder Gap
In almost every case the loss from zero to .001 was greater than the difference from .001 to .006 especially when the barrel was 6" or less
For instance the Cor-Bon 125gr 357 lost 49fps from zero to .001 and just 13fps from .001 to .006 with a 4" barrel.
There are some interesting variations, but most of the time the change from .001 to .006 was similar to most ammo's standard variation.
While i like .004 to -006 I don't believe a gap of .012 really losses that much velocity over .006.
They have a lot of information pertaining to barrel length, gab and different revolvers using .identical ammo, especially if you click on the raw data link and explore it
p.
But, my conclusion is there are several factors that will effect velocity as much or more than B/C gap