For all around general handgun uses I would pick a 4" M66 or M19. Light and portable enough to conceal and tote all day as well as accurate and easy to shoot well. The .357 mag is a very versatile cartridge and will do for hunting and protection as well as for target shooting and plinking. If one reloads, it is an easy cartridge to work with and it's cheap to shoot. Brass and bullets for .38/.357 are available everywhere...at least, they used to be before the recent insanity.