Best cartridge?

I too would choose .357 magnum, for many of the above stated reasons already mentioned.
 
That's like asking "what is the best golf club".

I would have to pick the 357.

Haha yeah it wasn't supposed to be a practical question, just to see what everyone likes best.

I also love 357s, my dad has a 66-2 and it's an awesome gun and lots of fun to shoot
 
38 special:

1 cheap to shoot if you reload
2 plenty of cases available
3. pleasant recoil (why get beat up shooting at paper or metalic targets)
4. fun fun fun
5. plenty of power for personal defense

What he said.
 
If I could have only one type cartridge it would be the .45 Colt. Load it heavy or load it light and anywhere in between. Perfect for action shooting, hunting and self-defense especially when topped off with a 300 gr. hollow point in front of a hefty load of Universal. It makes a good rifle round when out there in the brush huntin' hog. Only one drawback, if you shoot a lot you need to be reloadin'. It ain't a cheap round.
 
.357 Magnum. Capable of taking the largest game, great self defense round, accurate, and fun for target shooting. Fired from a Model 19, I think it is hard to beat by much of anything else.
 
As much as I love the 38 and 357, if I'm limited to only one cartridge (not one gun) I'd go with the 44 Special. Elmer knew what it was capable of, the 44 Magnum was well above what he asked for. Light bullets at sedate velocities for fun and plinking, heavy bullets at 1100-1200 fps for the serious stuff. Bullet selection for the .429's is as good as any caliber, with plenty of good defensive bullets if you need them. My personal choice of handguns would be a 4" 624.
 
I guess if I could have only one caliber it would be the .44 it can do it all properly loaded. If I could have 2 calibers it would be the 44 and the 22.
 
Since the OP doesn't restrict this discussion to handgun cartridges, I would suggest the .375 H&H is most useful. In handguns with factory ammo, my vote goes to the .22 LR cartridge. If we are talking chamberings and not restricting the discussion to factory ammo, I'd have to go with the .357 Magnum, specifically in a 6" N frame for the reasons given in above posts.
 
Another vote for 357. It can shoot 38 specials for plinking/fun/training new shooters. The 125 gr round is one of the best man-stoppers out there, and heavy loads will bring home dinner.
 
Everyone is right. It all depends on how you define "all around", what you like, where you live, whether you handload, what you have an opportunity to hunt, the gun the cartridge is going in, etc.

I am fortunate enough to have the reverse puzzling question. Out of all the guns I have that can do the job, which one am I going to take?

Assuming I had to use it for everything I might conceivably have a need for where I live in Texas, I'd pick .357 because you can also have a speedloader full of .38 spl for edible small game you don't want to blow to pieces.
 
My choice would be the .357 Mag, my students usually ask me if I could only have one gun, what would it be. I always tell them a 4" revolver in .357. Less moving parts never jam and over built, and the versatility of the .38/.357 for ammo.
 
The most versatile is also the most popular cartridge in all the world and that is the 22 Long Rifle. Think about it. It's lethal when well placed on just about anything that a human would reasonably take on. It's very inexpensive and finally it's easy to transport in volume.
 
My favorite is the .41 Magnum. Plenty of power, easy to control. .357 would be my next choice.
 
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