Of course, I can't say it with the weight of S&W policy, but I'm confident your average 4506 will take a steady diet of +Ps longer than you can. Provided, of course, you change out the recoil spring regularly (it's the singlemost important thing you can do to prolong a gun's service life).
Remember this platform was chambered for the 10mm, a cartridge with significantly more !omph! than +P 45ACP.