I routinely carry one or two of five pistols, but only one has a manual safety (my S&W PC M&P9 Shield M2.0). The manual safety was designed to be optional, and as commented above, I typically only use it to blind holster (when necessary) or holster appendix before turning it off again. I also have an M&P M2.0 Subcompact without a manual safety, and I carry both with a round in the chamber. My Ruger LCP II is the same way. It is a hammer fired gun without a manual safety. As many of you might know it is sort of a hybrid between an SA and a DAO that feels like a very crisp striker-fired trigger with a similar weight. All of the mentioned have triggers well above 5 lbs. (5.5-6 lbs. generally).
That said, I believe in mitigating risk, so these are not my preferred carry pistols, and if I could find quality DA/SA pistols with the same dimensions and similar ergonomics I would carry those instead. I more often than not carry appendix which allows me to carry larger firearms (my preference). My first choices are either my SIG P229 Elite chambered in .357 SIG or my Beretta PX4 Storm Compact Inox chambered in 9mm. These are DA/SA pistols without manual safeties, and they are safer in my opinion when carrying with a round in the chamber. Contrary to popular belief, the DA mode is superbly accurate so long as the pistol is dialed in to fit the user's hand properly. It is true some people have tried double action and can't get used to DA/SA, but most of the time I find they made little or no attempt to warm up to the pistol or even find grips and trigger sizes when necessary to adjust the length of pull.
Anyway, I am not saying carrying a striker-fired pistol without a manual safety with a round in the chamber is inherently dangerous for someone who knows what they are doing, but I do believe DA/SA is still safer, so when I can't conceal one of these DA/SA guns satisfactory, or if I'm just making a quick errand, I'll carry one of the smaller options, but my preference is to carry +1 for each.
All that said, don't listen to me or anyone else. You have to do you. We're all individuals and our circumstances vary. There are times when I have carried with an empty chamber even now after 16 years of concealed carry. If I have a lot on my mind, for example, it's rare but a voice sometimes calls out to me to leave the chamber empty. Woodworkers & carpenters understand this when using a table saw. Sometimes you need to decide against using one until you have your head screwed on straight. Do what works for you. As long as you go into it after having researched it thoroughly for yourself, don't be dissuaded by the unwise who feel everyone should carry as they do all the time. Too many people fall victim to groupthink, confirmation bias, and consciously or unconsciously seek validation for their choices.