Personally, I am very comfortable with my Kimber Pro Carry, Commander size, alloy frame, .45 ACP, night sights, 28 oz. weight. Anytime that I can wear an outer garment, that is my personal choice.
During very hot weather, when an outer garment is not desirable, I have found that the Kahr P40 stainless .40 S&W (polymer frame, 16.1 oz. weight) works well. Disappears under a golf shirt, but still delivers 7 rounds of 180-grain into a 4" group at 25 feet when I do my part right.
And my old S&W Model 37 Airweight Chief Special in .38 Special will never be far away from me! Too many years of being together!
Bottom line is this: the pistol you have with you will always be better than the one you left at home.
As a holster maker, I tell customers all the time that everything is a compromise (concealability, comfort, accessibility are the factors when it comes to a holster). Same reasoning applies. If it isn't concealable, you probably won't use it. If it isn't comfortable, you won't want to use it. If it isn't accessible, you might as well not have it with you.
Stay safe.