As I understand it, destroying plastic is the least of the problems with certain cleaners such as break cleaner. If the break cleaner contains Tetrachloroethylene, the combustion (heat) of the gun powder might cause the break cleaner to "decompose to harmful or fatal corrosive gases such as hydrogen chloride and possibly phosgene". Nasty stuff to breathe or get on your skin. Best to use approved gun cleaning solutions.
As to cleaning a brand new firearm, I would. As others have said, you want to make sure the firearm is in good working order before putting the first round through the barrel.
I see it as no different than someone handing you a firearm. Regardless whether the person handing you the firearm check to make sure the firearm was clear, it is your responsibility to double-check once handed to you. Smith and Wesson may have checked the 15-22 for functionality at the factory, but it is your responsibility to double-check functionality once the 15-22 is in your possession. Safety first.