I had the same feeling...
When we were out west we flew into Albuquerque and had a V-8 Thunderbird waiting for us. I made sure that we spent time traveling on parts of old 66. To me it was a blast. One night there was a tremendous storm and it got so DARK. It was a surreal feeling in that we were driving through space, or a worm hole or some such. So many people have traveled that highway for so many reasons that there's probably no end to the movies that could come out of that.
My wife and I are musicians but more retired due to a lot of trouble at home (Son who finally decided to get out of the 'street' business) has pushed other concerns to the forefront. We used to travel and do some concerts around the state. Both of us are singers and play a couple of instruments each. I used to know some people that were 'club' type musicians, but again, I'm out of circulation. We had the privilege one night of going to a pizza place and one of the waitresses set up a guitar and sound system and put on enough of a show for me to ask, "Man, what are you doing here?". One of my favorite joints when I was young had one-two person acts that were out of the mainstream enough to be really interesting.
I was helping my son get into music and he became a dynamite drummer at an early age, but he threw that in for the 'street life'. He did a little guitar, also, but didn't get anywhere near the level of his drumming. You know how you watch a kid and see what they are suited for. He's adopted so we had a wild card in that his personality was WAY different than either of ours. Well, it became obvious soon that he was a natural born drummer. This scared me a little because he began living a destructive life like a lot of rock drummers ie the 'Keith Moon' syndrome. My Dad asked me why I didn't get him to play violin or something similar. I told him that he didn't understand one bit and that if I gave my son a violin, he would break it in half in minutes just trying to play it.


(Funny, now he has a beautiful girlfriend that does play the violin.)
Well, I'm all for your Route 66 drive. I'd take along a 'Pignose' amp. We circled all around New Mexico and AZ.
Things to see while out there. Painted Desert, Petrified Forest, Meteor Crater (that's one huge hole in the ground) and the Grand Canyon are great things to see.
Well, good luck to you and Karen. You both have had a terrible time and deserve a little time free from hospitals.