One never knows what S&W will do. Who would have ever thought that they would produce a Scandium N-frame revolver chambered in 10mm with a 2.5" barrel? I wouldn't have -- but there it is, the S&W 310 Night Guard. They'll undertake a project like that (I don't think they are flying off the shelves), maybe they would undertake an M&P 10mm that would actually sell!
All that is needed is a new breechface on the slide, a new barrel, and an altered magazine -- certainly an easy engineering change with their CNC machining capability.
If someone would produce an aftermarket barrel for the M&P 45 in 10mm, I bet I could modify the existing magazines to make it work.
I've successfully converted a SigArms Mauser M2 as well as a new production AMT BackUp (currently made by High Standard in Houston) from .40 S&W to 10mm by modifying the barrels and magazines. Both of those were originally designed and built upon a .45 platform -- so it could be done.