The most successful python hunter is an older gentleman who works for one of the South Florida Water Management agencies. He slowly drives a F-series pickup along the canals and uses a 12 gauge. He has the vision and experience to eliminate them constantly.
The very big dead ones, especially during the touristy “Round-ups”, go to the University of Florida and other labs for dissection. 18 and 19 footers are found pretty regularly now.
They don’t rush out and strangle humans in the USA. It takes an experience hunter to find one. Raccoons, deer and similar mammals are easy prey for the snakes. These mammals are endangered in the Everglades because of the various python constrictor snakes have eaten them all.