I saw there was a vote for the 627 Pro. I'm going to vote with that one also. 8 shots of .357 or .38 Spec. Moon clip ready. Big, yes. Heavy, yes. Not the most concealable of my revolvers, but perhaps the most versatile. I bought it for IDPA/ICORE style games, but it will certainly fill the Bill for SD and hunting chores if called upon to do so. I'm not an open carry sort of guy, but if TSHTF, it rides real nicely in an OWB holster at about 4:00.
My favorite gun right now is my STI Trojan 9mm, but for an all around piece the 627 Pro is hard to beat.