I have taken all of my deer with the .44 Magnum revolver. I have two that I've actually taken deer with. One is my favorite Model 29 with 8 3/8" barrel. I mostly used my own cast 250 gr Keith bullets (429421 or H&G #503). I have never recovered a bullet (even two deer shot facing me had total penetration end to end).
My "bad weather" revolver was a Ruger Redhawk with 7½" barrel. I carried both of them, sometimes in VERY rough country, in a Bianchi Hush System across the chest holster. It was a near perfect way to carry a heavy and long revolver. Quite often I also carried a pack and had no problem with either item.
FWIW
Dale53