Funny how multiple threads on one particular gun pop up at the same time... Right now it's the 625 and the 637PC. I own both...
My 625 is magnificent. I changed out the grips since I have scar tissue in the web of my shooting hand. The large N-frame eats up the mild-pressure .45ACP and .45 Auto Rim. Can't comment much on fine accuracy, since I shoot at 1/2 sheets of typing paper at 5-7 yards, but I have no trouble with double taps on multiple targets. I call it 'shooting MOPP (Minute of Pie Plate).'
I use the moon clips with ACP and recommend getting one of the de- and -mooning tools for convenience. I find it harder to load the clips than unload them. The original style half-moon and 1/3 moon clips (clipping 2 rounds) are out there, but less handy. The 625 can use ACP without the clips in an emergency, but you have to punch them out with a pencil. Sometimes they fall out under gravity alone.
Another thought, I also have the modern mfg 1917 Model 22. One chamber is bored a smidge more deeply, so an ACP round therein may not ignite. The clips override this. Have already sent this one back because the sideplate was not fully seated. Can't make this stuff up!
Other posters will have more to say about reloaded ammo and pure accuracy. Hope I've helped a little.