ShrinkMD... I had an M625 Jerry Miculek version as my first Big-Bore Revolver but have multiple examples of .38Special Smith and Colt beforehand. I bought the M625 because of a problematic black bear at our mountain house and it was the perfect excuse to get into the Wonderful "N" frame Smiths that I've come to love the most out of any other handgun.
The first range day with the M625... the strain screw came loose/backed causing light strikes with Federal HST .45ACP's that are known for their soft, and easy to "touch-off" primers. I have a nice set of drivers made specifically for the screw/nut heads of S&W Revolvers. So I get her home on the bench and tighten every screw and the cylinder release nut on the gun really, really well. The next three range sessions 2-3 cylinders in it started happened with .45acp's, +P's, and most certainly shooting .45Supers all over again... Light primer strikes with strain screw backing out, cylinder release comes loose and off at range, yoke and side plate screws back out significantly; to the point I'd never carry it in the "Woods" or for anything else at that point... Then I did some research and was suggested Purple Loc-Tite... It's actually made for firearms and like applications. I cleaned and de-greased every screw, nut, post and hole in the gun that had previously backed out. Then I added two small dabs of the Purple Loc-Tite (with a toothpick) on all offending screws/nut & snugged them all back down & went 1/8th to 1/4 past snug as usual. The M625 to this day hasn't exhibited any of the aforementioned problems to this day and it receives a steady diet of 255 grain hard cast "Keith" topped .45Supers. I sold it to my little brother that just had to have it after he borrowed/shot it and his dedicated "Woods-Gun". I've since gotten into .44Specials & .44Magnums. The Purple Loc-Tite saved the M625 from being sold to a stranger. It's a great Revo now...
Best yet, when you want to take the side plate off for cleaning, adjusting, tuning, etc... the screws came out no problem with just a little more effort than normal but certainly Nothing hard or strenuous about it. Better than that attribute even... the threads came clean with minimal effort as well. When Loc-Tite says it's made for firearms and similar applications they mean it and my experience with Purple Loc-Tite is it matches their manufacturer's claim. I won't use any other kind of Loc-Tite other than the "Purple" kind.
The wife's new M642 "Airweight" (she loves her new Revo btw) exhibited the same exact problems as the M625 did after just one range session of only 90 rounds (and I tightened everything down before range day to be sure all was snug...) After the range date we had I performed the Same "Purple Loc-Tite" treatment and all has been beautiful after. I later did a trigger job just recently that resulted in dropping the almost 13lb trigger weight downto a deceivingly silky just under 8lb DA pull. All threads cleaned up well removing the previously added "Purple-Loc-Tite" when I did the recent trigger work. Once happy with the work I did to the trigger pull results... I reapplied (2) new dabs of the "Purple Loc-Tite" on the Yoke, and sideplate screws and snugged them down. Again, the results are Zero backing out under recoil and testing multiple kinds of ammo to ensure detonation after the trigger job.... I love the Purple Loc-Tite and everyone else (guys that recommended it to me first)... that has actually used it for this specific application has had the same experience as I have with it.
So, I'm going on the record here and saying:... I use and will always use "Purple Loc-Tite" for the above applications and recommend it to anyone who is constantly having stain screw, yoke screw, side plate screws, and the cylinder release nut constantly coming lose under recoil, range day, etc... The reason why... Not all Loc-Tite is the same and the "Purple" has resolved all the problems I've had with current production Smiths. Most importantly it's easy to remove and clean from any threads/screws it was applied to for when cleaning or tuning is desired; yet stays put when where and when you need it to...
Pic of my (now my brothers) M625 and the Wifey's M642 below...
I was just thinking that if there were some quality issues that I can see, perhaps there are others that may be less obvious. 
