I've liked the potential of the Gov since it was introduced, and continued to support S&W's betterment of the Judge despite some withering public criticism of the concept. Like all firearms, the Gov does have its limitations. I think it's best role is as a woods gun, or yard protector against various critters. For home defense? I'd go with a dedicated 20 or 12 gauge instead, perhaps even a lever gun or handgun depending on my home. The Gov would be formidable at close range for HD/SD, but it wouldn't be #1 on my list.
Also consider pricing. My LGS has a NIB Gov for $650. A Stoeger Coach Gun retails for $500, while a Mossberg 500 goes for $300-350. There are other viable alternatives, and I think the cost savings is a valid consideration whether or not to go with the Gov as the primary HD firearm.