I've had a 442-1 (Pro-series) relieved for moonclips, no lock for a couple months now.
Loose Rounds = ok.
Speed / Quik Strips = ok.
Speedloaders (HKS 36-A) = snug, but ok.
Moonclips = NoGo. Best ammo I've found so far has been Remingtons with the soft lead SWC HP (FBI load), but even those have been... difficult. They ride high enough that the drag on the frame makes a hard trigger pull almost impossible. With Double-Tap, Fiocchi, and Speer Gold Dots, I can't even get the cylinder to close.
As I've mentioned elsewhere, I love my 442 no-lock, but the moonclip option (at least so far) has not had ANY impact on me whatsoever.