I think you have to look at the long range picture. If you keep it in the safe, unfired, pristine, what happens when you are gone? If you have children that have the fever of gun collecting/shooting, then it will be in good hands. If you don't? Well it ends up in someone's collection or it ends up in someone's holster out in the field, or at the range or the worst case being turned into the police for distruction. I was standing in a local gunshop where a young woman brought in about a half dozen pistols, some pretty nice. Her husband had committed suicide with a gun and she wanted to get rid of the rest. She took them to the local PD and asked to have them destroyed. Fortunately, the officer told her to take them to a gunshop, put them on consignment and at least get money for her and her children out of them. Another officer might have taken them and they would have been made into steel ingots.
I am 53 years old and have been shooting and collecting since I was 10. My daughters like to shoot, but not as much as I do. I have quite a few bigbore rifles 375 and up, and several bigbore handguns. They have no desire to shoot the rifles and very limited on the handguns. They like the 22's, 38's and a few others.
I have started selling some of my collection, with their blessing, and using the money for other things. I still love to shoot and do so often, but am at that point in my life where I would rather stick with quality than quantity.
I regularly carry a 4" 29 and a 6.5" 5 screw pre-29 when I go shooting and/or hiking and hunting. My early 57 vintage pre-29 has taken quite a few rabbits, squirrels, and an occasional prarie dog.
I guess my point is, you have to make the decision as to what is most important to you...to keep a "museum" quality piece and enjoy it that way, or take it out shoot it, take very good care of it and although it won't be as nice as before, it will still be something special.
I don't think either way is better than the other, it all depends on you.